USO DE SULFATO DE MAGNÉSIO NA ANESTESIOLOGIA VETERINÁRIA

Abstract

Magnesium is used in veterinary medicine for the prevention and treatment of adverse conditions, the expansion of studies on its effects on the body, made magnesium to start being used for pain prophylaxis and later as an analgesic agent and anesthetic adjuvant when associated to anesthetics with the purpose of extending and prolonging the effects of the anesthetic, being administered intravenously in constant infusion, intramuscular application diluted to the anesthetic or epidurally

in some cases. Current studies demonstrate that magnesium acts in an inhibitory way to N-methyl- D-aspartate (NMDA) receptors, which are activated by glutamate and become permeable to

calcium and sodium, which act on the nervous membrane of the central nervous system, causing the intensification of depolarization, when blocked by magnesium, increases the excitatory threshold and presents an antinociceptive action. Another characteristic of magnesium is the natural competition with calcium, because of this attribute, magnesium prevents the influx of calcium into cells by closing these channels, reducing the release of enzymes capable of sensitizing the central nervous system, of substances related to the process inflammatory and glutamate, responsible for the excitability of NMDA receptors.